Highlights from Week 5:
Through five weeks of the 2016 season, the American Athletic Conference ranks fifth among the 10 NCAA FBS conferences in nonconference winning percentage.
| Conference | W-L | Pct. | |
| 1. | SEC | 28-7 | .417 |
| 2. | Big Ten | 32-9 | .780 |
| 3. | ACC | 33-10 | .767 |
| 4. | Pac-12 | 23-10 | . |